History & Culture

Western and Eastern traditions

	We follow the western tradition that evolved first in Europe
	In different regions of the west, perspectives sometimes differ

Other traditions in the middle east and far east evolved at roughly the same time and only now are coming together to form a shared perspective

Latin language

Latin, the language of the ancient Roman Empire, became the primary language of scholars in the west until the 20th century, because everyone who could read learned to read Latin before their own language

Most terminology in science, but especially in human biology, is therefore Latin in origin and usage

Latin borrows much from the ancient Greek language, and therefore so does scientific terminology

Word parts

	root - main part of the word
	prefix - word part added to the front of a root
	suffix - word part added to the end of a root
	Example: postsynaptic (root is "-synapt-" prefix is "post-" suffix is "-ic")

Eponym

Terms that use a person's name (usually whomever first identified it) or a place (usually the location of its discovery)

	Useful to learn history, but not as useful as a descriptive term for day-to-day use
	Many eponyms are now being replaced with Latin-based descriptive terms

If you want to know more about a person in an eponym click here

For medical conditions, the AMA (American Medical Association) style does not use the possessive form ('s)

Parkinson disease is proper whereas Parkinson's disease is improper (in the AMA style)

Required reading: Read p. 1 & 2 of the Quick Guide to the Language of Science and Medicine, which the pamphlet is inserted in your copy of Anatomy and Physiology 6th edition for a cartoon and explanation of MRI

Culture changes

Culture changes over time

Culture is different among different peoples at the same time

Culture influences the way we see the world and ourselves; it shapes the way we think

Culture influences the way we look at the human body, what questions we ask about it, and how we answer those questions

	For example, whether or not cadavers (human remains used for study) are dissected or not has depended upon the norms of the culture: it is acceptable and encouraged now, but not during the middle ages
	It has been acceptable to use animals for live experimentation but that may be changing right now in our own culture

A Traffic of Dead Bodies: Anatomy and Embodied Social Identity in Nineteenth-Century America, a book by Michael Sappol, explores the cultural tensions created by the use of dead bodies sometimes acquired by grave robbery and the public's desire for "anatomically trained doctors."

Some ethical questions . . .

A famous textbook of human anatomy, Pernkopf Anatomy, Atlas of Topographic and Applied Human Anatomy (2 volumes) by Dr. Eduard Pernkopf, features stunning artwork of cadavers and is considered a valuable classic in understanding the human body. However, there is good evidence to indicate that some of the cadavers used as models for this book were victims of the Nazi holocaust that were dissected at Dr. Pernkopf's lab at the University of Vienna, where the book was produced. A debate that has been raging since the mid-1990s centers around whether the book should still be used, considering the source of some of the cadavers. For more information, see NIH Record - 09-24-96 -- Anatomy Text Draws Criticism or InSCIght - 26 November 1996 Anatomy Text Linked to Nazi Victims (not required).

Assuming it contains useful illustrations, do you think the book should still be used?

The Visible Human Project sponsored by the NLM (National Library of Medicine) is an ongoing effort to use modern imaging techniques with cadavers to produce digital data that can be used for a variety of research and educational purposes. The first body used in the project, the Visible Man, belonged to a man executed by U.S. government

The National Library of Medicine's Visible Human Project

The Visible Human Project - Images & Animations

Considering the fact that a significant number of people are opposed to execution, do you think there are ethical concerns about using images from the Visible Human Project?

Gunther von Hagens has created an exhibit of dissected and plastinated human bodies called Body Worlds. Plastination converts tissues into durable plastic by chemical processes and is used with increasing frequencies among today's anatomists. Unlike most anatomists, however, van Hagens has depicted his specimens in active, sometimes provocative, positions. For example, a human body playing basketball. His work has created an ethical firestorm. Some believe that the body should not be represented in an artistic manner, while others argue that such artistry has been the tradition of scientific dissection.

You can visit the Body Worlds web site at BODYWORLDS-Home

What you do you think about Body Worlds? Is it ethical to exhibit human bodies in public in this manner? Does it serve education or science, or is it strictly asthetic?

Mary Roach's book STIFFS is a humorously written but scientifically accurate description of what happens to the human body after death. It includes a chapter on the educational/anatomical uses of human bodies.

Highly recommended reading!

Aristotle (384-322 BCE) of Greece

Along with his contemporary scientist-philosophers, Aristotle thought arteries contained air and veins carried blood. He had other "strange" ideas but was roughly accurate as far as the general anatomy of the human body.

Recognized that bodies are made of parts, which in turn are made of simpler parts

Recognized that similar organs in different organisms probably have similar functions

Thought the brain cooled the body and the heart heated it

Thought that the heart was the location of the mind, will, and emotions

Aristotle and others of his era did not rigorously question observations, as we do today.

From Aristotle's History of Animals (Chapter XIV):

". . . the heart is placed in the center; in man it is rather on the left side, inclining a little from the division of the mammae towards the left breast in the upper part of the chest; it is not large; its whole form is not long, but rather round, except that the extremity ends in a point. It has three cavities, as I have said. The greatest is that ton the right, the least on the left, the middle one is of intermediate size. They are all perforated towards the lungs."

Aristotle

Click to enlarge

"All men by nature desire to know." Aristotle (in Metaphysics)

Claudius Galen (129-199 CE) of Pergamon (now Turkey) (later, Rome)

Greek physician in the Roman Empire who performed experiments to prove arteries contain blood (but thought the heart was a single --not double--pump)

Many of Galen's conclusions were wrong because he used mostly animals after an early career using humans at a gladiatorial school outside Rome

Human dissection was forbidden in ancient Rome

From On Anatomical Procedure (Book I, Chapter II):

"Pursue by hard study, then, not only the descriptions of the bones in the book, but also acquaint yourself with the appearance of each of the bones, by the use your own eyes handling each bone by itself so that you become a first-hand observer. . . . I once examined the skeleton of a robber, lying on a mountain-side a short distance from the road. This man had been killed. . . and his body was eaten by birds of prey. . . As regards yourself, then, even if you do not have the luck to see anything like this, still you can dissect an ape, and learn each of the bones from it."

Galen was considered "the authority" until the Renaissance

During the Middle Ages, questioning Galen was questioning authority and because authority came from God, it was heresy and punishable by death --so NOBODY questioned Galen's conclusions

Diagram of Galen's concepts Galen's idea of blood flow

Galen treating a patient (Click to enlarge) In the painting to the left, Galen is shown "cupping" a patient. In this procedure, heated cups are applied to the patient's back. As the warm air in the cups cools, the air contracts and forms sucking force that draws blood toward the surface of the skin. Sometimes, cuts in the skin allow the cupping procedure to draw out the blood (a treatment known as blood-letting). Cupping was probably borrowed from the Eastern tradition and is still used today by some traditional healers.

"Employment is nature's physician" Claudius Galen

Andreas Vesalius (1514-1564 CE) of Brussels (later Padua, Italy)

Flemish anatomist willing to "use his own eyes" in human dissections correcting over 200 mistakes of Galen

During the middle ages, everyone had simply trusted Galen, but Vesalius and others during the Renaissance began to question and correct Galen

Vesalius was one of the first to dissect cadavers himself (rather than rely on others or on animal dissections); even Leonardo da Vinci and other "artist-anatomists" didn't do their own dissection (of course, they lived nearly twice as long because they weren't exposed to infections in the dead bodies)

Vesalius was obsessed with dissections, even stacking up cadavers in his bedroom as a medical student in Paris. Later in his life, he told his students to keep a list of their really sick patients so he'd know where to go to get a freshly dead body (yikes)

Published Concerning the Structure of the Human Body - De Corporis Humani Fabrica in 1543 (first "modern" human anatomy text) will detailed illustrations by Jan Stephan van Calcar (student of Titian) The Illustrations from the Works of Andreas Vesalius of Brussels     ACT

This book was published the same year as Copernicus's text, marking this year as the beginning of the "Scientific Revolution"

"It is perfectly clear to me that my attempt will have all too little authority because I have not yet passed the twenty-eighth year of my life; it is equally clear that, because of the numerous indications of the false dogmas of Galen, it will be exceedingly unsafe from the attacks of conservatives, who, as with us in the Italian schools, have constantly avoided anatomy, and who, being old men, will be consumed with envy because of the correct discoveries of the young, and will be ashamed at having been blind thus far, along with other followers of Galen."

Medieval dissection - notice that the professor
oversees the dissection and the dissector does the cutting

Click image to enlarge

Vesalius - Notice that Vesalius has come down from the podium
and does his own dissections

Francis Bacon (1561-1626 CE) of Great Britain

Published New Organon in 1620

Argued that inductive logic is better in science than deductive logic

Induction -- making general conclusions from specific facts or observations

Deduction -- making conclusions by inference from stated premises; drawing specific conclusions from general theories

Some consider Bacon the first to describe "the scientific method"

Sir Francis Bacon

"Knowledge is power." Francis Bacon

"Truth is the daughter of time, not of authority." Francis Bacon

William Harvey (1578-1657 CE) of Great Britain

English physician published The Anatomical Exercises - De Motu Cordis (1628) and De Circulatione Sanguinis (1649)

". . . blood does pass through the lungs and heart by the pulse of the ventricles, and is driven in and sent into the whole body, and does creep into the veins and porosities of the flesh, and through them returns from the little veins into the greater, from the circumference to the centre, from whence it comes at last into the vena cava, and into the ear of the heart in so great an abundance, with so great flux and reflux, from hence through the arteries thither, from thence through the veins hither back again, so that it cannot be furnished by those things which we do take in, and in a far greater abundance than is competent for nourishment: It must be of necessity concluded that the blood is driven into a round by a circular motion in creatures, and that it moves perpetually; and hence does arise the action and function of the heart, which by pulsation it performs; and lastly, that the motion and pulsation of the heart is the only cause." (Aren't you glad Harvey didn't write your textbook!)

Figure below shows one of many experiments that Harvey documents in his thorough proof that the heart is a double pump and how blood actually circulates.

Harvey is credited with beginning modern physiological research and experimentation

Harvey's experiment

William Beaumont (1785-1853 CE) of the United States (eventually, St. Louis)

Beaumont was an American army surgeon who, while stationed in Michigan, treated the 18-year-old Canadian Alexis St. Martin after an accidental short-range shotgun blast

The wound did not heal completely (see figure) and Beamount carefully recorded many experiments on gastric digestion in Experiments and Observations on the Gastric Juice and the Physiology of Digestion (1833)

"August 1, 1825. At 12 o'clock M., I introduced through the perforation, into the stomach, the following articles of diet, suspended by a silk string, and fastened at proper distances, so as to pass in without pain--vis.: a piece of high seasoned a la mode beef; a piece of raw, slated, fat pork; a piece of raw, salted, lean beef; a piece of boiled, salted beef; a piece of stale bread; and a bunch of raw, sliced cabbage; each piece weighing about two drachms; the lad continuing his usual employment about the house.
At 1 o'clock p.m., withdrew and examined them--found the cabbage, bread, pork, and boiled beef about half digested; the other pieces of meat unchanged. Returned them into the stomach.
At 2 o'clock p.m., withdrew them again--found the cabbage, bread, pork, and boiled beef, all cleanly digested, and gone from the string; the other pieces of meat but very little affected. Returned them to the stomach again."

"This experiment is important, in a pathological point of view. It confirms the opinion, that undigested portions of food in the stomach produce all the phenomena of fever; and is calculated to warn us of the danger of all excesses, where that organ is concerned."

Some controversy later developed over the use of human subjects; St. Martin kept returning for more experiments when he needed money, even going down to St. Louis occasionally after Beaumont moved there

	Beaumont is credited for being a pioneer in rigorous experimentation and detailed observation
	FYI After retiring from the army, Wm. Beaumont was asked to be the first head of St. Louis University's Medical School but he refused. He did leave a legacy to the school, however, and the SLU medical school was at one time named for him.

Wm. Beaumont

Click to enlarge

Mssr. St. Martin's wound

Claude Bernard (1813-1877 CE) of France

summarized modern principles of the scientific study of human biology in 1865 in Introduction to the Study of Experimental Medicine

"The true worth of an experimenter consists in his pursuing not only what he seeks in his experiment, but also what he did not seek."

Validates knowledge from proving hypotheses wrong

Bernard also made groundbreaking discoveries in the function of pancreatic juice, the existence of muscle that control blood vessel dilation, actions of curare and other drugs in neuromuscular function, and liver function

Bernard also was the first to articulate the concept of "relative constancy" of the body --or homeostasis-- a topic discussed in the Mini Lesson: Homeostasis.

Claude Bernard

"Art is I; science is we." Claude Bernard

Paul C Lauterbur	Peter Mansfield
for their discoveries concerning "magnetic resonance imaging" Imaging of human internal organs with exact and non-invasive methods is very important for medical diagnosis, treatment and follow-up. This year's Nobel Laureates in Physiology or Medicine have made seminal discoveries concerning the use of magnetic resonance to visualize different structures. These discoveries have led to the development of modern magnetic resonance imaging, MRI, which represents a breakthrough in medical diagnostics and research. Atomic nuclei in a strong magnetic field rotate with a frequency that is dependent on the strength of the magnetic field. Their energy can be increased if they absorb radio waves with the same frequency (resonance). When the atomic nuclei return to their previous energy level, radio waves are emitted. These discoveries were awarded the Nobel Prize in Physics in 1952. During the following decades, magnetic resonance was used mainly for studies of the chemical structure of substances. In the beginning of the 1970s, this year’s Nobel Laureates made pioneering contributions, which later led to the applications of magnetic resonance in medical imaging.
from http://www.nobel.se/medicine/laureates/2003/index.html
See page 18-19 of Anatomy and Physiology 6th edition for a cartoon and explanation of MRI